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Effect of an intra hypothalamic gene therapy with IGF 1 on behavioral parameters

Jeronimo Pennini

  • La Plata,
  • Argentina
  • Jeronimo Pennini ¹
  • , Franco Juan Cruz Dolcetti ¹
  • , Eugenia Falomir-Lockhart ¹
  • , Macarena Herrera ²
  • , María José Bellini ¹
  • 1 Instituto de Investigaciones Bioquímicas de La Plata “Profesor Doctor Rodolfo R. Brenner” (INIBIOLP)
  • 2 Instituto de Farmacología experimental de Córdoba (IFEC)

Aging is characterized by a coordinated organs and tissues functional impairment The hypothalamus, a region known to regulate many basic functions such as growth, development, reproduction and metabolism, is proposed as a regulatory center of aging Evidence demonstrates that the inhibition or activation of microglial or neural transcription factor NF κB of the basal hypothalamus ( affects the life expectancy and the ” of aging, as well as the release of GnRH There is solid evidence that middle age ( rats do not respond to estradiol positive feedback with an appropriate modulation of excitatory and inhibitory hypothalamic neurotransmitter release This imbalance could cause reduced activation of GnRH neurons, reduced GnRH release, and an abnormal LH surge The MA rat brain reduction of factors like IGF 1 could be the reason of the affected modulation on excitatory and inhibitory hypothalamic release These findings provide a link between inflammation, response to stress and systemic and cerebral aging.
It is well known that IGF 1 plays a physiological role in neuroprotection and neuroinflammation. We decided to investigate the effects of intrahypothalamic gene therapy for IGF 1 in MA rats .We propose that transgenic IGF 1 will modulate neuroinflammation and delay reproductive senescence.