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Major Depressive Disorder and Borderline Personality Disorder: Emotional regulation and neuroimaging

Vicente Camacho-Téllez

  • CABA,
  • Argentina
  • Vicente Camacho-Telléz ¹
  • , Agustina Wainsztein ¹
  • , Mariana Castro ¹
  • , Mirta Villarreal ²
  • , Salvador Guinjoan ³
  • 1 Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta. FLENI, Buenos Aires, Argentina.
  • 2 Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Argentina.
  • 3 Servicio de Psiquiatría. FLENI, Buenos Aires.

Emotional problems figure in many clinical conditions (Sheppes, 2015), such as Major Depressive Disorder (MDD) or Borderline Personality Disorder (BPD) (Vitriol, 2017). Both disorders share clinical and biological characteristics, included the emotion’s neural circuit (Goodman, 2010).
The objective is to describe the differences in cortical thickness, brain volumetry, cognitive emotional regulation between both disorders and to explore the correlation between emotional regulation and cortical thickness. Materials and methods: 19 MDD patients, 18 BPD and 20 healthy controls were recruited. Cognitive Emotional Regulation Questionnaire (CERQ) was applied. MRI were obtained with a GE 3T scanner and processed with FreeSurfer 6.0 toolset. CERQ’s score and volume structures were compared. Pearson’s correlation for correlation between CERQ and cortical thickness. Results: CERQ score is higher in MDD patients compared to controls, [X2(1)=10.35] (p<0.01). Hippocampal volume is lower in BPD patients compared to controls: F(2,54)=4.71; p <0.05. Globus pallidus, volume is lower in BPD patients compared to both groups: F(2,54)=6.89; p <0.01. Cortical thickness is lower in BPD patients compared to controls (p<0.05). At higher score in CERQ, lower cortical thickness in left inferiorparietal region in MDD group (p<0.05; r = -0.58). Conclusions: There are differences in cortical thickness, hippocampal and globus pallidus volume. Cortical thickness is modulated by emotional regulation.